Cadherin-5 - CISMeF

Preferred Label : Cadherin-5;

NCIt synonyms : Vascular Endothelial Cadherin 1; Vascular Endothelial Cadherin; CDH5; VE-Cadherin; 7B4 Antigen; CD144 Antigen; Cadherin 5; Endothelial-Specific Cadherin;

NCIt definition : Cadherin-5 (784 aa, 88 kDa) is encoded by the human CDH5 gene. This protein is involved in endothelial cell polarity and cell-cell adhesion.;

NCIt note : Encoded by human CDH5 Gene (CDH Family), 784-amino acid 87.5 kD (precursor) Vascular Endothelial Cadherin is a Ca(2 )-dependent homophilic endothelial cell-cell adhesion type I membrane glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Expressed specifically in endothelial cells and brain, VE-Cadherin is found mainly at cell-cell boundaries, associated with intercellular junctions. CDH5 may play a role in endothelial cell cohesion and organization of intercellular junctions. CDH5/beta-catenin signaling may control endothelial survival. CDH5 associates with alpha-catenin, forming a link to the cytoskeleton.;

Details

Origin ID

C21021;

UMLS CUI

C1741231;

False automatic mappings
- cadherin 5 [MeSH concept]
- cadherin 5 [MeSH Supplementary Concept]
OMIM relation
- Cadherin 5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CDH5 protein, human [MeSH concept]
- cadherin 5 [MeSH Supplementary Concept]
- cadherin 5 [MeSH concept]
gene_encodes_gene_product
- CDH5 Gene [NCIt concept]
- Cell Adhesion Molecule Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Brain [NCIt concept]
- Endothelium [NCIt concept]
gene_product_has_associated_anatomy
- Cell Junction [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Calcium Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cadherin Domain [NCIt concept]
- Cytoplasmic Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_is_element_in_pathway
- Cell Adhesion Molecule Signaling Pathway [NCIt concept]
- Leukocyte Transendothelial Migration Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Calcium Binding [NCIt concept]
- Cell Adhesion Process [NCIt concept]
- Ligand Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

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