" /> SELE wt Allele - CISMeF





Preferred Label : SELE wt Allele;

NCIt synonyms : ELAM1; LECAM2; Selectin E wt Allele; CD62E; ELAM; CD62E Gene; ESEL; Endothelial Leukocyte Adhesion Molecule 1 Gene; Selectin E (Endothelial Adhesion Molecule 1) Gene;

NCIt definition : Human SELE wild-type allele is located within 1q22-q25 and is approximately 11 kb in length. This allele, which encodes E-selectin protein, plays a role in the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. Variant alleles may be involved in the pathogenesis of atherosclerosis.;

NCIt note : ELAM1 exon-intron boundaries correlate with putative functional regions of the protein. Mediating cell adhesion binding of endothelial cells to leukocytes, such as Neutrophils, during inflammatory responses, ELAM1 recognizes glycolipid polylactosamine derivatives and may be involved in the pathogenesis of atherosclerosis. An aa149 polymorphism is associated with higher risk of coronary artery disease and ELAM1 is a diagnostic indicator of glaucoma.;

GenBank Accession Number : NM_000450;

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16/05/2024


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