Complement C4-A

Preferred Label : Complement C4-A;

NCIt synonyms : Rodgers Form of C4; C3 and PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 2; Acidic C4; Complement Component 4S; Acidic Complement C4; Complement Component 4A; C4A;

NCIt definition : Complement C4-A (1744 aa, 193 kDa) is encoded by the human C4A gene. This protein plays a role in both host defense and inflammation.;

NCIt note : Complement C4-A and Complement C4-B differ by 4 amino acids at positions 1101-1106; C4A has the sequence PCPVLD, while C4B has the sequence LSPVIH. (OMIM); Complement C4-A is cleaved into the following 6 chains: complement C4 beta chain, complement C4-A alpha chain, C4a anaphylatoxin, C4b-A, C4d-A, and complement C4 gamma chain. Mature complement C4-A circulating in the blood is a disulfide-linked trimer of the C4-A alpha, C4 beta and C4 gamma chains. (UniProt);

Détails

Origin ID

C128865;

UMLS CUI

C4283921;

Automatic exact mappings (from CISMeF team)
- Complement component 4a [OMIM gene]
Currated CISMeF NLP mapping
- Complement C4a [LOINC component]
- Complement component C4a (substance) [SNOMED CT concept]
- complement C4a [MeSH Descriptor]
- complement C4a [MeSH concept]
OMIM relation
- Complement component 4a [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
Validated automatic mappings to NTBT
- Complement C4 [LOINC component]
- complement C4 [MeSH Descriptor]
- complement C4 [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- C4A Gene [NCIt concept]
- Complement Component Gene [NCIt concept]
gene_product_expressed_in_tissue
- Blood [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Complement [NCIt concept]
- Complement Component-4 [NCIt concept]
gene_product_is_element_in_pathway
- Classical Complement Pathway [NCIt concept]
- Complement Pathway [NCIt concept]
- Complement and Coagulation Cascade [NCIt concept]
- Lectin Induced Complement Pathway [NCIt concept]
- Systemic Lupus Erythematosus Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Complement Activation [NCIt concept]
- Immunity [NCIt concept]

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