" /> Complement C1r Subcomponent - CISMeF





Preferred Label : Complement C1r Subcomponent;

NCIt synonyms : EC 3.4.21.41; Complement Component 1 Subcomponent R; C1R; Complement C1r;

NCIt definition : Complement C1r subcomponent (705 aa, 80 kDa) is encoded by the human C1R gene. This protein is involved in the proteolytic activation of complement C1s subcomponent.;

NCIt note : Complement C1 complex is composed of 1 molecule of C1q, 2 molecules of C1r and 2 molecules of C1s. When antigen-antibody complexes, pentraxins or pathogens bind C1q, its conformation changes and causes activation of C1r. Active C1r cleaves C1s into A (heavy) and B (light) chains. The C1s B chain contains the active site that cleaves an Arg-/-Ala bond in complement component C4 to form C4a and C4b, and a Lys(or Arg)-/-Lys bond in complement component C2 to form C2a and C2b. (UniProt);

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29/04/2024


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