C5a Anaphylatoxin Chemotactic Receptor 1

Preferred Label : C5a Anaphylatoxin Chemotactic Receptor 1;

NCIt synonyms : C5a Anaphylatoxin Receptor; C5AR1; CD88 Antigen; C5a Anaphylatoxin Chemotactic Receptor; C5a-R; Complement Component 5 Receptor 1; Complement C5a Receptor 1; C5a Ligand; CD88; C5aR; Complement Component 5a Receptor 1;

NCIt definition : C5a anaphylatoxin chemotactic receptor 1 (350 aa, 39 kDa) is encoded by the human C5AR1 gene. This protein is involved in neutrophil degranulation, complement activation, inflammation and chemotaxis.;

NCIt note : C5a anaphylatoxin chemotactic receptor 1 may play a role in antiphospholipid syndrome and pregnancy loss. (OMIM);

Details

Origin ID

C182149;

UMLS CUI

C1454453;

Automatic exact mappings (from CISMeF team)
- CD88 [LOINC component]
- Complement component 5a receptor 1 [OMIM gene]
- complement C5a receptor 1 [HGNC gene]
- receptor, anaphylatoxin C5a [MeSH concept]
- receptor, anaphylatoxin c5a [MeSH Descriptor]
OMIM relation
- Complement component 5a receptor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- C5AR1 protein, human [MeSH Supplementary Concept]
- C5AR1 protein, human [MeSH concept]
gene_encodes_gene_product
- C5AR1 Gene [NCIt concept]
- Chemokine Receptor Gene [NCIt concept]
- Cytokine Receptor Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Blood [NCIt concept]
- Peripheral Blood Cell [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Complement and Coagulation Cascade [NCIt concept]
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Chemotactic Process [NCIt concept]
- Complement Activation [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Degranulation [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Immunoregulation [NCIt concept]
- Inflammatory Response [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Avdoralimab [NCIt concept]
- Izastobart [NCIt concept]

Keyword's position in hierarchy(ies) :

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