" /> Avdoralimab - CISMeF





Preferred Label : Avdoralimab;

NCIt synonyms : Anti-C5aR-215;

NCIt definition : A human monoclonal antibody targeting the C5a receptor (C5aR), with potential immunomodulating activity. Upon administration, avdoralimab specifically targets, binds to and blocks C5aR expressed on subsets of myeloid-derived suppressor cells (MDSCs) and neutrophils. This prevents the binding of its ligand C5a to C5aR and prevents the C5aR-mediated activation and accumulation of these cells in the tumor microenvironment (TME), and abrogates the secretion of inflammatory and angiogenic factors by these cells. This results in the activation of T- and natural killer (NK) cells, the induction of anti-tumor immune responses and inhibits tumor cell proliferation. C5a, a factor in the complement cascade, is often overexpressed in tumors, where it attracts and activates MDSCs and neutrophils in the TME.;

UNII : DW4CE8MKS9;

CAS number : 2226393-85-5;

Molecule name : IPH 5401; IPH-5401; NN 8210;

NCI Metathesaurus CUI : CL973370;

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29/05/2025


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