Complement C1s Subcomponent

Preferred Label : Complement C1s Subcomponent;

NCIt synonyms : C1 Esterase; EC 3.4.21.42; Complement Component 1 Subcomponent S; C1S; Complement C1s;

NCIt definition : Complement C1s subcomponent (688 aa, 77 kDa) is encoded by the human C1S gene. This protein plays a role in the proteolytic activation of complement components C2 and C4.;

NCIt note : Complement C1 complex is composed of 1 molecule of C1q, 2 molecules of C1r and 2 molecules of C1s. When antigen-antibody complexes, pentraxins or pathogens bind C1q, its conformation changes and causes activation of C1r. Active C1r cleaves C1s into A (heavy) and B (light) chains. The C1s B chain contains the active site that cleaves an Arg-/-Ala bond in complement component C4 to form C4a and C4b, and a Lys(or Arg)-/-Lys bond in complement component C2 to form C2a and C2b. (UniProt);

NCI Metathesaurus CUI : CL1647979;

Details

Origin ID

C178161;

UMLS CUI

C5553028;

Automatic exact mappings (from CISMeF team)
- Complement C1s [LOINC component]
- Complement component 1, s subcomponent [OMIM gene]
- Complement component C1s (substance) [SNOMED CT concept]
- complement C1 [MeSH Descriptor]
- complement C1 [MeSH concept]
- complement C1s [MeSH Descriptor]
- complement C1s [MeSH concept]
- complement C1s [ORDO Gene]
- complement C1s [HGNC gene]
OMIM relation
- Complement component 1, s subcomponent [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- C1S Gene [NCIt concept]
- Complement Component Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Complement [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Sushi Domain [NCIt concept]
gene_product_is_element_in_pathway
- Classical Complement Pathway [NCIt concept]
- Complement and Coagulation Cascade [NCIt concept]
- Systemic Lupus Erythematosus Pathway [NCIt concept]
gene_product_is_physical_part_of
- Complement Component C1 [NCIt concept]
gene_product_plays_role_in_biological_process
- Complement Activation [NCIt concept]
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]
- Proteolytic Processing [NCIt concept]

Keyword's position in hierarchy(ies) :

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