Complement Component C1

Preferred Label : Complement Component C1;

NCIt synonyms : C1 Complex; C1; Complement System C1 Complex; Complement C1; Complement Component C1 Complex;

NCIt definition : A protein complex composed of the following complement component 1 (C1) moieties, two C1r chains, two C1s chains and one C1q complex. C1 plays a role in the activation of the classical complement pathway. Binding of pentraxins or antibody-antigen complexes containing either immunoglobulin M (IgM) or several monomeric IgG molecules to the C1q complex moiety causes confirmational changes in C1q that activate the C1r chains. In turn, active C1r cleaves the C1s chains. Then cleaved C1s proteolytically activates C2 and C4 and promotes formation of C3-convertase, which can both cleave C3 and activate the classical complement pathway.;

NCI Metathesaurus CUI : CL1907592;

Details

Origin ID

C198549;

UMLS CUI

C0009499;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- Complement C1 [LOINC component]
- Complement component C1 (substance) [SNOMED CT concept]
- complement C1 [MeSH Descriptor]
- complement C1 [MeSH concept]
- complement component c1, nos [SNOMED Notion]
gene_encodes_gene_product
- Complement Component Gene [NCIt concept]
gene_product_has_biochemical_function
- Complement [NCIt concept]
gene_product_plays_role_in_biological_process
- Complement Activation [NCIt concept]
has_gene_product_element
- Complement C1q Subcomponent Subunit A [NCIt concept]
- Complement C1q Subcomponent Subunit B [NCIt concept]
- Complement C1q Subcomponent Subunit C [NCIt concept]
- Complement C1r Subcomponent [NCIt concept]
- Complement C1s Subcomponent [NCIt concept]
- Complement Component C1q [NCIt concept]

Keyword's position in hierarchy(ies) :

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