Preferred Label : complement C1s;
MeSH definition : A 77-kDa subcomponent of complement C1, encoded by gene C1S, is a SERINE PROTEASE
existing as a proenzyme (homodimer) in the intact complement C1 complex. Upon the
binding of COMPLEMENT C1Q to antibodies, the activated COMPLEMENT C1R cleaves C1s
into two chains, A (heavy) and B (light, the serine protease), linked by disulfide
bonds yielding the active C1s. The activated C1s, in turn, cleaves COMPLEMENT C2 and
COMPLEMENT C4 to form C4b2a (CLASSICAL C3 CONVERTASE).;
MeSH synonym : esterase, complement 1; c1 esterase; c 1 esterase; component 1s, complement; complement 1s; esterase, c 1; c1s complement; complement component 1s; complement 1 esterase; esterase, c1; c1s, complement; complement, C1s;
Registry Number MeSH : EC 3.4.21.42;
Is substance : O;
UNII : EC 3.4.21.42;
Origin ID : D003173;
UMLS CUI : C0009504;
Allowable qualifiers
- Currated CISMeF NLP mapping
- Pharmacological action(s)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
A 77-kDa subcomponent of complement C1, encoded by gene C1S, is a SERINE PROTEASE
existing as a proenzyme (homodimer) in the intact complement C1 complex. Upon the
binding of COMPLEMENT C1Q to antibodies, the activated COMPLEMENT C1R cleaves C1s
into two chains, A (heavy) and B (light, the serine protease), linked by disulfide
bonds yielding the active C1s. The activated C1s, in turn, cleaves COMPLEMENT C2 and
COMPLEMENT C4 to form C4b2a (CLASSICAL C3 CONVERTASE).
