complement C1 - CISMeF

Preferred Label : complement C1;

MeSH definition : The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION.;

MeSH synonym : c1, complement; complement component 1; complement 1; component 1, complement; c1 complement; complement, C1;

MeSH annotation : /antag permitted but consider also COMPLEMENT C1 INACTIVATOR PROTEINS;

Is substance : O;

Details

Origin ID

D003172;

UMLS CUI

C0009499;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Complement C1s [LOINC component]
- Complement C1s Subcomponent [NCIt concept]
- Complement component C1 (substance) [SNOMED CT concept]
- Complement component C1s (substance) [SNOMED CT concept]
- Complement factor C1 [MedDRA LLT]
- complement C1s [ORDO Gene]
- complement C1s [HGNC gene]
- complement component c1, nos [SNOMED Notion]
Indexing information
- BSF 468248 [MeSH Supplementary Concept]
Pharmacological action(s)
- immunologic factors [MeSH Descriptor]
Record concept(s)
- complement C1 [MeSH concept]
Related MeSH Supplementary Concept(s)
- C1qL4 protein, mouse [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- Complement C1 [LOINC component]
- Complement component C1 (substance) [SNOMED CT concept]
- complement component c1, nos [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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