Complement C4-B

Preferred Label : Complement C4-B;

NCIt synonyms : Complement Component 4F; Chido Form of C4; Basic Complement C4; C3 and PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 2; Basic C4; Complement Component 4B; C4B;

NCIt definition : Complement C4-B (1744 aa, 193 kDa) is encoded by the human C4B and C4B_2 genes. This protein is involved in the propagation of the classical complement pathway.;

NCIt note : Complement C4-A and Complement C4-B differ by 4 amino acids at positions 1101-1106; C4A has the sequence PCPVLD, while C4B has the sequence LSPVIH. (OMIM); Complement C4-B is cleaved into the following 6 chains: complement C4 beta chain, complement C4-B alpha chain, C4a anaphylatoxin, C4b-B, C4d-B, and complement C4 gamma chain. (UniProt);

Details

Origin ID

C128866;

UMLS CUI

C4283922;

Currated CISMeF NLP mapping
- complement C4b [MeSH Descriptor]
- complement C4b [MeSH concept]
OMIM relation
- Complement component 4b [OMIM gene]
See also inter- (CISMeF)
- Complement component 4b [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- C4B Gene [NCIt concept]
- C4B_2 Gene [NCIt concept]
- Complement Component Gene [NCIt concept]
gene_product_expressed_in_tissue
- Blood [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Complement [NCIt concept]
- Complement Component-4 [NCIt concept]
gene_product_is_element_in_pathway
- Classical Complement Pathway [NCIt concept]
- Complement Pathway [NCIt concept]
- Complement and Coagulation Cascade [NCIt concept]
- Lectin Induced Complement Pathway [NCIt concept]
- Systemic Lupus Erythematosus Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Complement Activation [NCIt concept]
- Immunity [NCIt concept]

Keyword's position in hierarchy(ies) :

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