Acylation Stimulating Protein

Preferred Label : Acylation Stimulating Protein;

NCIt synonyms : C3a Anaphylatoxin desArg; C3adesArg; Complement Component C3adesArg; C3a des Arg; Complement C3adesArg; Acylation-Stimulating-Protein; ASP; Acylation-Stimulating Protein;

NCIt definition : Acylation stimulating protein (76 aa, 9 kDa) is encoded by the human C3 gene. This protein is involved in stimulating glucose uptake, triglyceride synthesis and nonesterified fatty acid storage in adipocytes.;

NCIt note : Acylation stimulating protein (ASP) is comprised of amino acids 672-747 of complement C3 and is produced through proteolysis of complement C3 into a C-terminal alpha chain and a N-terminal beta chain (C3b) followed by further modification of the alpha chain C-terminus yielding C3a anaphylatoxin. Then C3a anaphylatoxin is rapidly cleaved by either carboxypeptidase B or N, which remove the C-terminal arginine residue, to generate acylation stimulating protein.;

NCI Metathesaurus CUI : CL1773615;

Details

Origin ID

C182444;

UMLS CUI

C5575341;

Automatic exact mappings (from CISMeF team)
- Agouti signaling protein [OMIM gene]
- Apobec1 complementation factor [OMIM gene]
- Autophagy-related 5 [OMIM gene]
- Rhophilin associated tail protein 1-like [OMIM gene]
- aspartoacylase [ORDO Gene]
- assembly factor for spindle microtubules [ORDO Gene]
- complement C3a, des-Arg-(77)- [MeSH Supplementary Concept]
OMIM relation
- Complement component 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- C3 Gene [NCIt concept]
- Complement Component Gene [NCIt concept]
- Cytokine Gene [NCIt concept]
gene_product_has_associated_anatomy
- Central Nervous System [NCIt concept]
- Epithelial Cell [NCIt concept]
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Adipokine [NCIt concept]
- Complement [NCIt concept]
- Protein Fragment [NCIt concept]
gene_product_plays_role_in_biological_process
- Adipogenesis [NCIt concept]
- Chemotactic Process [NCIt concept]
- Complement Activation [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Glucose Transport Induction [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Leukocyte Trafficking [NCIt concept]
- Maturation [NCIt concept]
- Triglyceride Metabolism [NCIt concept]

Keyword's position in hierarchy(ies) :

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