Clusterin - CISMeF

Preferred Label : Clusterin;

NCIt synonyms : NA1/NA2; TRPM-2; Complement Cytolysis Inhibitor; Apolipoprotein J; Aging-Associated Gene 4 Protein; Complement-Associated Protein SP-40,40; Testosterone-Repressed Prostate Message 2; CLI; Apo-J; Ku70-Binding Protein 1; Sulfated Glycoprotein 2; Complement Lysis Inhibitor;

NCIt definition : Clusterin (449 aa, 52 kDa) is encoded by the human CLU gene. This protein may be involved in lipid metabolism, complement regulation and the initiation of apoptosis.;

NCIt note : Clusterin can be cleaved into alpha and beta chains that are also known as ApoJ alpha and ApoJ beta. The two chains form an antiparallel disulfide-linked heterodimer. (UniProt);

Details

Origin ID

C84432;

UMLS CUI

C1453673;

Currated CISMeF NLP mapping
- Apolipoprotein J (substance) [SNOMED CT concept]
- Clusterin [LOINC component]
- clusterin [MeSH Descriptor]
- clusterin [MeSH concept]
OMIM relation
- Clusterin [OMIM gene]
See also inter- (CISMeF)
- Clusterin [MedDRA Preferred Term]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CLU protein, human [MeSH concept]
- CLU protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CLU Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
gene_product_has_biochemical_function
- Lipoprotein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_is_element_in_pathway
- Classical Complement Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Alzheimer's Disease [NCIt concept]
gene_product_plays_role_in_biological_process
- Complement Activation [NCIt concept]
- Ligand Binding [NCIt concept]
- Lipid Metabolic Process [NCIt concept]
- Transport Process [NCIt concept]
is_target
- Custirsen Sodium [NCIt concept]
- Sotevtamab [NCIt concept]

Keyword's position in hierarchy(ies) :

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