" /> Custirsen Sodium - CISMeF





Preferred Label : Custirsen Sodium;

NCIt synonyms : TRPM-2 Antisense; (3'-5')d(P-thio)([2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2- methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]m5rC-A-G-C-A-G-A-G-T-C-T-T-C-A-[2'-O-(2- methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2- methoxyethyl)]m5rU), Eicosasodium Salt; Antisense TRPM-2; Antisense Testosterone-Repressed Prostate Message 2; Clusterin Antisense Oligonucleotide;

NCIt definition : The eicosasodium salt of a mixed-backbone antisense oligodeoxynucleotide with chemosensitizing properties. Custirsen inhibits testosterone-repressed prostate message-2 (TRPM-2). Administration of custirsen abrogates the anti-apoptotic effect of TRPM-2, thereby sensitizing cells to chemotherapy and resulting in tumor cell death. TRPM-2 is an anti-apoptotic clusterin that is overexpressed by prostate cancer cells and is associated with chemoresistance.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It blocks the production of a protein called clusterin, which helps cells live longer. This may kill cancer cells that need clusterin to grow. It may also make cells more sensitive to anticancer drugs. It is a type of antisense oligonucleotide, and a type of chemosensitizing agent.;

UNII : ILE26V76EB;

CAS number : 685922-56-9;

Molecule name : ISIS 112989; OGX-011; OGX 011;

Chemical formula : C231H292N78O119P20S20.20Na;

Codes from synonyms : CDR0000649042;

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08/05/2025


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