NCIt definition : The eicosasodium salt of a mixed-backbone antisense oligodeoxynucleotide with chemosensitizing
properties. Custirsen inhibits testosterone-repressed prostate message-2 (TRPM-2).
Administration of custirsen abrogates the anti-apoptotic effect of TRPM-2, thereby
sensitizing cells to chemotherapy and resulting in tumor cell death. TRPM-2 is an
anti-apoptotic clusterin that is overexpressed by prostate cancer cells and is associated
with chemoresistance.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It blocks the production
of a protein called clusterin, which helps cells live longer. This may kill cancer
cells that need clusterin to grow. It may also make cells more sensitive to anticancer
drugs. It is a type of antisense oligonucleotide, and a type of chemosensitizing agent.;
UNII : ILE26V76EB;
CAS number : 685922-56-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 685922-56-9
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