NCIt definition : A mixed-backbone antisense oligodeoxynucleotide, with potential chemosensitizing activity.
Upon administration, custirsen prevents the translation of testosterone-repressed
prostate message-2 (TRPM-2). This abrogates the anti-apoptotic effect of TRPM-2, thereby
sensitizing cells to chemotherapy and resulting in tumor cell death. TRPM-2 is an
anti-apoptotic clusterin that is overexpressed by prostate cancer cells and is associated
with chemoresistance.;