" /> Custirsen - CISMeF





Preferred Label : Custirsen;

NCIt definition : A mixed-backbone antisense oligodeoxynucleotide, with potential chemosensitizing activity. Upon administration, custirsen prevents the translation of testosterone-repressed prostate message-2 (TRPM-2). This abrogates the anti-apoptotic effect of TRPM-2, thereby sensitizing cells to chemotherapy and resulting in tumor cell death. TRPM-2 is an anti-apoptotic clusterin that is overexpressed by prostate cancer cells and is associated with chemoresistance.;

UNII : L26E95NLRK;

CAS number : 890056-27-6;

NCI Metathesaurus CUI : CL1382220;

Codes from synonyms : 120;

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Keyword's position in hierarchy(ies) : arborescence

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31/05/2025


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