Custirsen - CISMeF

Preferred Label : Custirsen;

NCIt definition : A mixed-backbone antisense oligodeoxynucleotide, with potential chemosensitizing activity. Upon administration, custirsen prevents the translation of testosterone-repressed prostate message-2 (TRPM-2). This abrogates the anti-apoptotic effect of TRPM-2, thereby sensitizing cells to chemotherapy and resulting in tumor cell death. TRPM-2 is an anti-apoptotic clusterin that is overexpressed by prostate cancer cells and is associated with chemoresistance.;

UNII : L26E95NLRK;

CAS number : 890056-27-6;

NCI Metathesaurus CUI : CL1382220;

Codes from synonyms : 120;

Details

Origin ID

C169869;

UMLS CUI

C4079860;

Currated CISMeF NLP mapping
- custirsen [MeSH concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
has_salt_form
- Custirsen Sodium [NCIt concept]
is_free_acid_or_base_form_of
- Custirsen Sodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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