" /> Sotevtamab - CISMeF





Preferred Label : Sotevtamab;

NCIt synonyms : Anti-sCLU Monoclonal Antibody AB-16B5;

NCIt definition : A humanized, immunoglobulin (Ig) G2 monoclonal antibody against the secreted form of human clusterin (sCLU) expressed by tumor cells, with potential antineoplastic and anti-metastatic activities. Upon administration, sotevtamab specifically binds to tumor-associated sCLU and inhibits its activity. This inhibits both the sCLU-mediated signal transduction pathways and epithelial-to-mesenchymal transition (EMT), which leads to the inhibition of tumor cell migration and invasion. In addition, sotevtamab enhances chemo-sensitivity. sCLU, a heterodimeric disulfide-linked glycoprotein overexpressed by various types of cancer cells, contributes to proliferation and survival of cancer cells, and stimulates tumor cell EMT.;

UNII : YQ3YJK67AF;

CAS number : 2411526-47-9;

Molecule name : AB-16B5;

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10/05/2025


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