NCIt definition : A humanized, immunoglobulin (Ig) G2 monoclonal antibody against the secreted form
of human clusterin (sCLU) expressed by tumor cells, with potential antineoplastic
and anti-metastatic activities. Upon administration, sotevtamab specifically binds
to tumor-associated sCLU and inhibits its activity. This inhibits both the sCLU-mediated
signal transduction pathways and epithelial-to-mesenchymal transition (EMT), which
leads to the inhibition of tumor cell migration and invasion. In addition, sotevtamab
enhances chemo-sensitivity. sCLU, a heterodimeric disulfide-linked glycoprotein overexpressed
by various types of cancer cells, contributes to proliferation and survival of cancer
cells, and stimulates tumor cell EMT.;
UNII : YQ3YJK67AF;
CAS number : 2411526-47-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2411526-47-9
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Semantic type(s)