Mannan-Binding Lectin Serine Protease 2

Preferred Label : Mannan-Binding Lectin Serine Protease 2;

NCIt synonyms : Mannose-Binding Lectin-Associated Serine Protease 2; Mannose-Binding Protein-Associated Serine Protease 2; MASP-2; MBL Associated Serine Protease 2; EC 3.4.21.104; MASP2; MBL-Associated Serine Protease 2; Mannan Binding Lectin Serine Peptidase 2;

NCIt definition : Mannan-binding lectin serine protease 2 (686 aa, 76 kDa) is encoded by the human MASP2 gene. This protein plays a role in the cleavage of complement components C2 and C4.;

NCIt note : An alternative spliced transcript produces a C-terminally truncated active form called Mannose-binding lectin associated protein 19 (Map19, small MBL-associated protein, sMAP).; Upon mannan-binding lectin binding, the mannan-binding lectin serine protease 2 preproprotein is autoproteolytically cleaved C-terminal to the arginine at position 444. This generates A and B chains that heterodimerize via at least one interchain disulfide bond to form the mature protease. (UniProt);

Details

Origin ID

C181978;

UMLS CUI

C0537643;

Automatic exact mappings (from CISMeF team)
- MBL associated serine protease 2 [HGNC gene]
- MBL associated serine protease 2 [ORDO Gene]
- Mannan-binding lectin serine protease 2 [OMIM gene]
OMIM relation
- Mannan-binding lectin serine protease 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MASP2 protein, human [MeSH Supplementary Concept]
- MASP2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- MASP2 Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
- Plasma [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Sushi Domain [NCIt concept]
gene_product_is_element_in_pathway
- Complement and Coagulation Cascade [NCIt concept]
- Lectin Induced Complement Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Complement Activation [NCIt concept]
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]
is_target
- Narsoplimab [NCIt concept]

Keyword's position in hierarchy(ies) :

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