Pancreatic Elastase

Preferred Label : Pancreatic Elastase;

NCIt synonyms : CELA Family; CELA; Chymotrypsin-Like Elastase; Chymotrypsin-Like Elastase Family;

NCIt definition : A family of chymotrypsin-like serine proteinases that specifically hydrolyze amino bonds on the carboxyl side of hydrophobic amino acids, including alanine, leucine, methionine and phenylalanine. These enzymes play roles in digestion and pancreatic regulation of insulin. Elastin is a substrate for some members of the family. Measurement of the concentration of certain pancreatic elastase isoforms in feces can be correlated to the exocrine secretory capacity of the pancreas.;

NCIt note : Humans express five pancreatic elastases: CELA1, CELA2A, CELA2B, CELA3A and CELA3B. CELA1 is not expressed by the pancreas.;

NCI Metathesaurus CUI : CL1905122;

Details

Origin ID

C191858;

UMLS CUI

C0030306;

Currated CISMeF NLP mapping
- Elastase.pancreatic [LOINC component]
- Pancreatic elastase (substance) [SNOMED CT concept]
- pancreatic elastase [MeSH Descriptor]
- pancreatic elastase [MeSH concept]
- pancreatic elastase [SNOMED Notion]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Elastase [LOINC component]
- Elastase.pancreatic [LOINC component]
- Pancreatic elastase (substance) [SNOMED CT concept]
- pancreatic elastase [MeSH Descriptor]
- pancreatic elastase [MeSH concept]
- pancreatic elastase [SNOMED Notion]
Validated automatic mappings to NTBT
- Elastase [LOINC component]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Serine Protease [NCIt concept]
gene_product_plays_role_in_biological_process
- Digestion [NCIt concept]
- Environment-to-Cell Communication [NCIt concept]
- Protein Degradation Process [NCIt concept]
- Proteolysis [NCIt concept]
is_chemical_classification_of_gene_product
- Chymotrypsin-Like Elastase Family Member 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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