Chymotrypsin-Like Elastase Family Member 1

Preferred Label : Chymotrypsin-Like Elastase Family Member 1;

NCIt synonyms : EC 3.4.21.36; Elastase-1; Pancreatic Elastase 1; Elastase 1; CELA1;

NCIt definition : Chymotrypsin-like elastase family member 1 (258 aa, 28 kDa) is encoded by the human CELA1 gene. This protein is involved in protein hydrolysis.;

NCIt note : Chymotrypsin-like elastase family member 1 has a synonym of Pancreatic Elastase 1; however, this protein is not detected in the pancreas.; Chymotrypsin-like elastase family member 1 preferentially cleaves proteins after alanine residues and substrates include elastin, fibrin, hemoglobin, and albumin. (UniProt);

Details

Origin ID

C115178;

UMLS CUI

C3890046;

Automatic exact mappings (from CISMeF team)
- Chymotrypsin-like elastase family, member 1 [OMIM gene]
- chymotrypsin like elastase 3B [HGNC gene]
OMIM relation
- Chymotrypsin-like elastase family, member 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CELA1 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_chemical_classification
- Pancreatic Elastase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Protein Degradation Process [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients