Granzyme M - CISMeF

Preferred Label : Granzyme M;

NCIt synonyms : Lymphocyte Met-Ase 1; GZMM; Natural Killer Cell Granular Protease; Met-1 Serine Protease; EC 3.4.21.-; Hu-Met-1; Met-Ase;

NCIt definition : Granzyme M (257 aa, 28 kDa) is encoded by the human GZMM gene. This protein is involved in the cleavage of protein and peptide substrates.;

NCIt note : Granzyme M cleaves after methionine, leucine and norleucine. Its substrates include ezrin, alpha-tubulins and the baculoviral IAP repeat-containing protein 5 (BIRC5; Survivin).;

Details

Origin ID

C148330;

UMLS CUI

C1700559;

Automatic exact mappings (from CISMeF team)
- Granzyme M [OMIM gene]
- Hu-Met-1 [MeSH Supplementary Concept]
- Hu-Met-1 [MeSH concept]
- granzyme M [HGNC gene]
- granzyme M [MeSH concept]
- granzymes [MeSH Descriptor]
- metaseal [MeSH concept]
- metaseal [MeSH Supplementary Concept]
OMIM relation
- Granzyme M [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- GZMM protein, human [MeSH concept]
- GZMM protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- GZMM Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Activated Natural Killer Cell [NCIt concept]
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Endopeptidase [NCIt concept]
- Granzyme [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Caspase Activation [NCIt concept]
- Hydrolysis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Positive Regulation of Cell Death [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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