granzymes - CISMeF

Preferred Label : granzymes;

MeSH definition : A family of serine endopeptidases found in the SECRETORY GRANULES of LEUKOCYTES such as CYTOTOXIC T-LYMPHOCYTES and NATURAL KILLER CELLS. When secreted into the intercellular space granzymes act to eliminate transformed and virus-infected host cells.;

MeSH synonym : Granzyme;

MeSH hyponym : granzyme C; granzyme K; granzyme B; granzyme A; granzyme M; Natural Killer Cell Granule Tryptase-2; Natural Killer Cell Granule Tryptase 2; NK-Tryptase-2; NK Tryptase 2; Granzyme-3; Granzyme 3; Cytotoxic T-Lymphocyte Proteinase 1; Cytotoxic T Lymphocyte Proteinase 1; Hanukah Factor; Fragmentin 2; Cytotoxic T-Lymphocyte Associated 1 Protein; Cytotoxic T Lymphocyte Associated 1 Protein; Granzyme-Like Protein III; Granzyme Like Protein III; Cytotoxic Serine Protease B;

MeSH Related Number : granzyme M; granzyme C; granzyme K; granzyme A; granzyme B; EC 3.4.21.78;

Registry Number MeSH : EC 3.4.21.-;

Related CAS MeSH : EC 3.4.21.- (Granzyme M); EC 3.4.21.- (Granzyme C); EC 3.4.21.- (Granzyme K); EC 3.4.21.78 (Granzyme A); EC 3.4.21.- (Granzyme B);

Wikipedia link : https://en.wikipedia.org/wiki/Granzyme;

Is substance : O;

Details

Origin ID

D053804;

UMLS CUI

C1333877;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Granzyme [NCIt concept]
Pharmacological action(s)
- cytotoxins [MeSH Descriptor]
Record concept(s)
- granzyme A [MeSH concept]
- granzyme B [MeSH concept]
- granzyme C [MeSH concept]
- granzyme K [MeSH concept]
- granzyme M [MeSH concept]
- granzymes [MeSH concept]
Related MeSH Supplementary Concept(s)
- GZMA protein, human [MeSH Supplementary Concept]
- GZMB protein, human [MeSH Supplementary Concept]
- GZMH protein, human [MeSH Supplementary Concept]
- GZMK protein, human [MeSH Supplementary Concept]
- GZMM protein, human [MeSH Supplementary Concept]
- GzmK protein, mouse [MeSH Supplementary Concept]
- granzyme A, mouse [MeSH Supplementary Concept]
- gzmb protein, mouse [MeSH Supplementary Concept]
- gzmb protein, rat [MeSH Supplementary Concept]
- gzmc protein, mouse [MeSH Supplementary Concept]
- gzmc protein, rat [MeSH Supplementary Concept]
- gzmd protein, mouse [MeSH Supplementary Concept]
- gzme protein, mouse [MeSH Supplementary Concept]
- gzmf protein, mouse [MeSH Supplementary Concept]
- gzmg protein, mouse [MeSH Supplementary Concept]
- gzmm protein, mouse [MeSH Supplementary Concept]
- gzmm protein, rat [MeSH Supplementary Concept]
- gzmn protein, mouse [MeSH Supplementary Concept]
- perforin-granzyme B [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Granzyme [NCIt concept]

Keyword's position in hierarchy(ies) :

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