Preferred Label : Fluorine F 18 LY3546117;
NCIt synonyms : 18F-LY3546117;
NCIt definition : A radioconjugate composed of the granzyme B-targeting agent LY3546117 labeled with
the radionuclide fluorine F 18, with potential use as an imaging agent for granzyme
B activity upon positron emission tomography (PET). Upon administration, fluorine
F 18 LY3546117 targets and binds to granzyme B. Granzyme B activity can then be visualized
using PET. Granzyme B plays a key role in cytotoxic T-lymphocyte (CTL) and natural
killer (NK) cell-mediated cytotoxicity of virus-infected cells and tumor cells.;
NCI Metathesaurus CUI : CL1662415;
Origin ID : C179666;
UMLS CUI : C5555856;
Semantic type(s)
- concept_is_in_subset
- has_target
