MS4A2 wt Allele

Preferred Label : MS4A2 wt Allele;

NCIt synonyms : IGER; IGEL; Membrane-Spanning 4-Domains, Subfamily A, Member 2 wt Allele; FCERI; MS4A1; IGHER; ATOPY; IgE Responsiveness (Atopic) Gene; APY; FCER1B;

NCIt definition : Human MS4A2 wild-type allele is located within 11q12-q13 and is approximately 10 kb in length. This allele, which encodes high affinity immunoglobulin epsilon receptor subunit beta protein, plays a role in both immunoglobulin binding and mast cell responses.;

NCIt note : A mutation in the MS4A2 gene may be associated with mast cell leukemia. (Leukemia doi:10.1038/leu.2011.354.);

GenBank Accession Number : M89796;

Details

Origin ID

C101624;

UMLS CUI

C3539705;

Automatic exact mappings (from CISMeF team)
- Atopic reaction (disorder) [SNOMED CT concept]
- Atopy [PASCAL descriptor]
- Atopy [MedDRA Preferred Term]
- Atopy (finding) [SNOMED CT concept]
- Ige responsiveness, atopic [OMIM Phenotype]
- Membrane-spanning 4 domains, subfamily a, member 1 [OMIM gene]
- Membrane-spanning 4 domains, subfamily a, member 2 [OMIM gene]
- dermatitis, atopic [MeSH Descriptor]
- membrane spanning 4-domains A1 [ORDO Gene]
False automatic mappings
- atopy [Disease (Nov.)]
OMIM relation
- Membrane-spanning 4 domains, subfamily a, member 2 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 11q12-q13 [NCIt concept]
gene_is_element_in_pathway
- Asthma Pathway [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway BioCarta [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Fc-Epsilon Receptor I Signaling Pathway PID [NCIt concept]
gene_plays_role_in_process
- Cell Proliferation [NCIt concept]
- Humoral Immunity [NCIt concept]
- Immune System Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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