Preferred Label : Fluticasone;
NCIt definition : A synthetic trifluorinated glucocorticoid receptor agonist with antiallergic, antiinflammatory
and antipruritic effects. Fluticasone binds and activates glucocorticoid receptor,
resulting in the activation of lipocortin. Lipocortin, in turn, inhibits cytosolic
phospholipase A2, which triggers a cascade of reactions involved in the synthesis
of inflammatory mediators, such as prostaglandins and leukotrienes. Secondly, mitogen-activated
protein kinase (MAPK) phosphatase 1 is induced, thereby leads to dephosphorylation
and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription.
Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby
inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin
production.;
UNII : CUT2W21N7U;
InChIKey : MGNNYOODZCAHBA-GQKYHHCASA-N;
CAS number : 90566-53-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 90566-53-3
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Chemical formula : C22H27F3O4S;
Origin ID : C61767;
UMLS CUI : C0082607;
- Automatic exact mappings (from CISMeF team)
- CISMeF manual mappings
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
https://dumas.ccsd.cnrs.fr/dumas-04169231
2023
France
dissertations, academic
Efficacy Study
Systematic Review
Fluticasone
efficiency
Legal Adult
asthma, nos
review literature as topic
Asthma
asthma
Asthma Pathway
adult
Fluticasone
Reviewing
classification
asthma
adulthood
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