Fluticasone - CISMeF

Preferred Label : Fluticasone;

NCIt definition : A synthetic trifluorinated glucocorticoid receptor agonist with antiallergic, antiinflammatory and antipruritic effects. Fluticasone binds and activates glucocorticoid receptor, resulting in the activation of lipocortin. Lipocortin, in turn, inhibits cytosolic phospholipase A2, which triggers a cascade of reactions involved in the synthesis of inflammatory mediators, such as prostaglandins and leukotrienes. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leads to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production.;

UNII : CUT2W21N7U;

InChIKey : MGNNYOODZCAHBA-GQKYHHCASA-N;

CAS number : 90566-53-3;

Chemical formula : C22H27F3O4S;

Details

Origin ID

C61767;

UMLS CUI

C0082607;

CISMeF manual mappings
- Fluticasone [MeSH Descriptor]
Currated CISMeF NLP mapping
- Fluticasone [MeSH concept]
- Fluticasone [ICD-11 Extension code]
- Fluticasone [SMS substance]
- Fluticasone (substance) [SNOMED CT concept]
See also inter- (CISMeF)
- Product containing fluticasone (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Fluticasone [MeSH Descriptor]
- Fluticasone (substance) [SNOMED CT concept]
- Product containing fluticasone (medicinal product) [SNOMED CT concept]
- fluticasone [ATC Code]
- fluticasone [ATC Code]
- fluticasone [ATC Code]
Validated automatic mappings to BTNT
- fluticasone [ATC Code]
- fluticasone [ATC Code]
- fluticasone [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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