Mepolizumab - CISMeF

Preferred Label : Mepolizumab;

NCIt definition : A humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against interleukin-5 (IL-5) with anti-asthmatic and potential immunosuppressive activity. Upon subcutaneous administration, mepolizumab selectively binds to IL-5, preventing it from associating with interleukin-5 receptor subunit alpha (IL5RA) on the surface of eosinophils and their progenitors. IL-5 plays a role in the regulation of eosinophil development from hematopoietic progenitors as well as eosinophil maturation, differentiation, mobilization, activation, and survival. IL-5 also play a role in the pathogenesis of some phenotypes of hypereosinophilic syndrome (HES).;

UNII : 90Z2UF0E52;

CAS number : 196078-29-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 196078-29-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Nucala; Bosatria;

Molecule name : SB 240563; SB-240563;

NCI Metathesaurus CUI : CL936998;

Codes from synonyms : 326;

Details

Origin ID

C157376;

UMLS CUI

C0969324;

Automatic exact mappings (from CISMeF team)
- Mepolizumab [ICD-11 Extension code]
Currated CISMeF NLP mapping
- Mepolizumab (substance) [SNOMED CT concept]
- mepolizumab [MeSH Supplementary Concept]
- mepolizumab [MeSH concept]
See also inter- (CISMeF)
- Product containing mepolizumab (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Mepolizumab (substance) [SNOMED CT concept]
- Product containing mepolizumab (medicinal product) [SNOMED CT concept]
- mepolizumab [ATC Code]
- mepolizumab [MeSH concept]
- mepolizumab [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- mepolizumab [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Interleukin-5 Receptor Subunit Alpha [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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