Preferred Label : Autologous Bladder Cell Carcinoma RNAs/CD40L RNA Electroporated Autologous Matured
Dendritic Cells;
NCIt synonyms : Autologous DCs Electroporated with Autologous Tumor-derived IVT RNAs/CD40L IVT RNA; Autologous DCs Electroporated with Autologous Tumor-derived RNAs/CD40L RNA; Bladder Cell Carcinoma RNAs/CD40L RNA-transfected Autologous Dendritic Cells;
NCIt definition : A cell-based preparation in which autologous, mature dendritic cells (DCs) are electroporated
with in vitro transcribed (IVT) RNAs encoding for a synthetic form of T-cell protein
CD40 ligand (CD40L) and IVT RNA encoding for autologous tumor-associated antigens
(TAAs) derived from patient-specific bladder cell carcinoma (BCC) cells, with potential
immunostimulatory and antineoplastic activities. Upon electroporation into autologous
DCs, the RNA is translated and processed. BCC-specific antigenic peptides are subsequently
presented via major histocompatibility complex (MHC) Class I molecules on the DCs
surface. When AGS-003-BLD is reintroduced to the patient, the MHC-presented peptides
interact with and activate CD8-positive T-cells, which elicits a highly specific cytotoxic
T-cell (CTL) response against tumor cells expressing the patient-specific BCC TAAs.
The signal cascade initiated by expression of the co-stimulatory molecule CD40L results
in the secretion of the inflammatory cytokine IL-12, which further stimulates CTLs.;
Molecule name : AGS-003-BLD;
NCI Metathesaurus CUI : CL512599;
Origin ID : C129522;
UMLS CUI : C4329368;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
