Galiximab - CISMeF

Preferred Label : Galiximab;

NCIt synonyms : anti-B7-1; anti-CD80 Antibody; IDEC-114 Monoclonal Antibody;

NCIt definition : A chimeric IgG1 monoclonal antibody directed against CD80, the natural ligand for the T-cell antigen CD28 which mediates T-cell and B-cell adhesion. Galiximab binds to CD80 expressed on the cell surfaces of follicular lymphomas, resulting in antibody-dependent cell-mediated cytotoxicity (ADCC). CD80 is expressed on activated B-cells and gamma-interferon-stimulated monocytes and is often expressed at low levels on the surfaces of follicular lymphoma cells and other lymphoid malignancies.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of follicular non-Hodgkin lymphoma. It binds to the protein CD80, which is found on certain normal white blood cells and on white blood cells that are cancer. It is a type of monoclonal antibody.;

UNII : S9OX9692ZB;

CAS number : 357613-77-5;

Molecule name : IDEC-114;

NSC code : 734532;

Codes from synonyms : CDR0000446802;

Details

Origin ID

C26447;

UMLS CUI

C1098262;

Currated CISMeF NLP mapping
- galiximab [MeSH concept]
- galiximab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- galiximab [MeSH concept]
- galiximab [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- T-Lymphocyte Activation Antigen CD80 [NCIt concept]
is_component_of_chemotherapy_regimen
- IDEC-114 Monoclonal Antibody/Rituximab [NCIt concept]

Keyword's position in hierarchy(ies) :

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