Preferred Label : Type 1 diabetes mellitus;
Symbol : T1D;
CISMeF acronym : IDDM; IDDM1; JOD; T1D;
Type : Phenotype or locus, molecular basis unknown;
Alternative titles and symbols : Diabetes mellitus, insulin-dependent; Juvenile-onset diabetes; JOD; IDDM;
Included titles and symbols : Diabetes mellitus, insulin-dependent, 1; Insulin-dependent diabetes mellitus 1; IDDM1; Type 1 diabetes mellitus 1; T1D1;
Description : The type of diabetes mellitus called IDDM is a disorder of glucose homeostasis that
is characterized by susceptibility to ketoacidosis in the absence of insulin therapy.
It is a genetically heterogeneous autoimmune disease affecting about 0.3% of Caucasian
populations (Todd, 1990). Genetic studies of IDDM have focused on the identification
of loci associated with increased susceptibility to this multifactorial phenotype.
The classical phenotype of diabetes mellitus is polydipsia, polyphagia, and polyuria
which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These
derangements result in long-term complications that affect the eyes, kidneys, nerves,
and blood vessels.;
Inheritance : Autosomal recessive susceptibility; heterogeneous;
Prefixed ID : %222100;
Origin ID : 222100;
UMLS CUI : C0011854;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- DO Cross reference
- Genes related to phenotype
- HPO term(s)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
