Preferred Label : Immune-related Type 1 diabetes mellitus;
ICD-11 definition : This form, previously called insulin-dependent diabetes or juvenile-onset diabetes,
accounts for 5–10% of diabetes and is due to cellular-mediated autoimmune destruction
of the pancreatic β-cells. Autoimmune markers include islet cell autoantibodies and
autoantibodies to GAD (GAD65), insulin, the tyrosine phosphatases IA-2 and IA-2β,
and ZnT8. Type 1 diabetes is defined by the presence of one or more of these autoimmune
markers. The disease has strong HLA associations, with linkage to the DQA and DQB
genes. These HLA-DR/DQ alleles can be either predisposing or protective. The rate
of β-cell destruction is quite variable, being rapid in some individuals (mainly infants
and children) and slow in others (mainly adults).;
ICD-11 synonym : Juvenille onset diabetes mellitus; Immune-mediated Type 1 diabetes mellitus;
ICD-11 inclusion : Latent autoimmune diabetes in adults; SPIDDM - [Slowly progressive insulin-dependent diabetes mellitus]; slowly progressive insulin-dependent diabetes mellitus; LADA - [Latent autoimmune diabetes in adults];
Origin ID : 1727622794;
UMLS CUI : C0011854;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
This form, previously called insulin-dependent diabetes or juvenile-onset diabetes,
accounts for 5–10% of diabetes and is due to cellular-mediated autoimmune destruction
of the pancreatic β-cells. Autoimmune markers include islet cell autoantibodies and
autoantibodies to GAD (GAD65), insulin, the tyrosine phosphatases IA-2 and IA-2β,
and ZnT8. Type 1 diabetes is defined by the presence of one or more of these autoimmune
markers. The disease has strong HLA associations, with linkage to the DQA and DQB
genes. These HLA-DR/DQ alleles can be either predisposing or protective. The rate
of β-cell destruction is quite variable, being rapid in some individuals (mainly infants
and children) and slow in others (mainly adults).
