Serine/Threonine-Protein Kinase/Endoribonuclease IRE1

Preferred Label : Serine/Threonine-Protein Kinase/Endoribonuclease IRE1;

NCIt synonyms : IRE1a; hIRE1p; Inositol-Requiring Protein 1; Ire1-alpha; Endoplasmic Reticulum-To-Nucleus Signaling 1; Inositol-Requiring Enzyme 1; ERN1;

NCIt definition : Serine/threonine-protein kinase/endoribonuclease IRE1 (977 aa, 110 kDa) is encoded by the human ERN1 gene. This protein is involved in both protein phosphorylation and mRNA processing in response to endoplasmic reticulum stress-dependent signaling.;

NCIt note : Serine/threonine-protein kinase/endoribonuclease IRE1 has both serine/threonine kinase activity (EC 2.7.11.1) and endoribonuclease activity (EC 3.1.26.-). (UniProt);

Details

Origin ID

C113614;

UMLS CUI

C2353079;

Automatic exact mappings (from CISMeF team)
- Endoplasmic reticulum-to-nucleus signaling 1 [OMIM gene]
- endoplasmic reticulum to nucleus signaling 1 [HGNC gene]
OMIM relation
- Endoplasmic reticulum-to-nucleus signaling 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- ERN1 protein, human [MeSH Supplementary Concept]
- ERN1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ERN1 Gene [NCIt concept]
- Endoribonuclease Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Ribonuclease Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Endoplasmic Reticulum [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alzheimer's Disease Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- RNA Splicing [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Stress Response Signaling [NCIt concept]
is_target
- IRE1 RNase Inhibitor ORIN1001 [NCIt concept]

Keyword's position in hierarchy(ies) :

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