cGMP-Specific 3',5'-Cyclic Phosphodiesterase

Preferred Label : cGMP-Specific 3',5'-Cyclic Phosphodiesterase;

NCIt synonyms : CGB-PDE; EC 3.1.4.35; cGMP-Binding cGMP-Specific Phosphodiesterase; PDE5A;

NCIt definition : cGMP-specific 3',5'-cyclic phosphodiesterase (875 aa, 100 kDa) is encoded by the human PDE5A gene. This protein plays a role in the mediation of cyclic GMP metabolism.;

Details

Origin ID

C95469;

UMLS CUI

C1447683;

OMIM relation
- Phosphodiesterase 5a [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PDE5A protein, human [MeSH concept]
- PDE5A protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- PDE5A Gene [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Purine Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Avanafil [NCIt concept]
- Exisulind [NCIt concept]
- Sildenafil [NCIt concept]
- Sildenafil Citrate [NCIt concept]
- Sulindac [NCIt concept]

Keyword's position in hierarchy(ies) :

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