NCIt definition : An inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac. After
oral administration, sulindac undergoes extensive biotransformation including irreversible
oxidation to sulindac sulfone. Approximately, one half of an administered dose of
sulindac is eliminated through the urine, mostly as the conjugated sulfone metabolite.
(NCI04);
Alternative definition : NCI-GLOSS: A drug being studied in the treatment and prevention of cancer. It has
been shown to cause apoptosis (cell death) in cells that are malignant (cancer) and
in cells that may become cancer. It acts through a group of cellular enzymes called
cGMP phosphodiesterases.;
UNII : K619IIG2R9;
InChIKey : MVGSNCBCUWPVDA-MFOYZWKCSA-N;
CAS number : 59973-80-7;
Drug name : Aptosyn;
Molecule name : FGN-1;
Chemical formula : C20H17FO4S;
NSC code : 719619;
ChEBI ID : CHEBI:64212;
Codes from synonyms : NSC0719619; 08937; CDR0000046015;