Preferred Label : Sildenafil Citrate;
NCIt related terms : sildenafil; Viagra;
NCIt definition : The citrate salt form of sildenafil, an orally bioavailable pyrazolopyrimidinone derivative
structurally related to zaprinast, with vasodilating and potential anti-inflammatory
activities. Upon oral administration, sildenafil selectively targets and inhibits
cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), thereby
inhibiting the PDE5-mediated degradation of cGMP found in smooth muscle and increasing
cGMP availability. This results in prolonged smooth muscle relaxation in the corpus
cavernosum of the penis, thereby causing vasodilation, blood engorgement and a prolonged
penile erection. In the smooth muscle of the pulmonary vasculature, the increase in
cGMP results in smooth muscle relaxation, vasodilation of the pulmonary vascular bed,
relieving pulmonary hypertension and increasing blood flow in the lungs. In addition,
sildenafil may reduce airway inflammation and mucus production.;
Alternative definition : NCI-GLOSS: A drug used to treat erectile dysfunction. Viagra relaxes the smooth muscle
of the penis to allow increased blood flow and erection. It is a type of phosphodiesterase
inhibitor.;
UNII : BW9B0ZE037;
InChIKey : DEIYFTQMQPDXOT-UHFFFAOYSA-N;
CAS number : 171599-83-0;
Drug name : Viagra; Revatio;
Chemical formula : C22H30N6O4S.C6H8O7;
ChEBI ID : CHEBI:58987;
Codes from synonyms : CDR0000306517; CDR0000306518; 20611;
Origin ID : C26670;
UMLS CUI : C0724693;
Automatic exact mappings (from CISMeF team)
- CISMeF manual mappings
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
