Sildenafil - CISMeF

Preferred Label : Sildenafil;

NCIt definition : An orally bioavailable pyrazolopyrimidinone derivative structurally related to zaprinast, with vasodilating and potential anti-inflammatory activities. Upon oral administration, sildenafil selectively targets and inhibits cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), thereby inhibiting the PDE5-mediated degradation of cGMP found in smooth muscle and increasing cGMP availability. This results in prolonged smooth muscle relaxation in the corpus cavernosum of the penis, thereby causing vasodilation, blood engorgement and a prolonged penile erection. In the smooth muscle of the pulmonary vasculature, the increase in cGMP results in smooth muscle relaxation, vasodilation of the pulmonary vascular bed, relieving pulmonary hypertension and increasing blood flow in the lungs. In addition, sildenafil may reduce airway inflammation and mucus production.;

Alternative definition : NCI-GLOSS: A drug used to treat erectile dysfunction. Sildenafil relaxes the smooth muscle of the penis to allow increased blood flow and erection. It is a type of phosphodiesterase inhibitor.;

UNII : 3M7OB98Y7H;

InChIKey : BNRNXUUZRGQAQC-UHFFFAOYSA-N;

CAS number : 139755-83-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 139755-83-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C22H30N6O4S;

ChEBI ID : CHEBI:9139;

Codes from synonyms : CDR0000306517;

Details

Origin ID

C61940;

UMLS CUI

C0529793;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing sildenafil (medicinal product) [SNOMED CT concept]
- Sildenafil [ICD-11 Extension code]
- Sildenafil (substance) [SNOMED CT concept]
- sildenafil [ATC Code]
- sildenafil [Substance BNPC]
- sildenafil [International Nonproprietary Name]
- sildenafil [MeSH concept]
Validated automatic mappings to BTNT
- Sildenafil Citrate [MeSH Descriptor]
- sildenafil [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_salt_form
- Sildenafil Citrate [NCIt concept]
has_target
- cGMP-Specific 3',5'-Cyclic Phosphodiesterase [NCIt concept]
is_free_acid_or_base_form_of
- Sildenafil Citrate [NCIt concept]

Keyword's position in hierarchy(ies) :

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