Avanafil - CISMeF

Preferred Label : Avanafil;

NCIt synonyms : (S)-4-(3-Chloro-4-methoxybenzylamino)-2-(2-hydroxymethylpyrrolidin-1-yl)-N-pyrimidin-2-ylmethyl-5-pyrimidinecarboxamide;

NCIt definition : An orally available phosphodiesterase type 5 (PDE5) inhibitor with vasodilatory activity. Avanafil selectively inhibits PDE5, thus inhibiting the degradation of cyclic guanosine monophosphate (cGMP) found in the smooth muscle of the corpus cavernosa of the penis. The inhibition of cGMP degradation results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, thereby prolonging penile erection.;

UNII : DR5S136IVO;

InChIKey : WEAJZXNPAWBCOA-INIZCTEOSA-N;

CAS number : 330784-47-9;

Drug name : Stendra;

Molecule name : TA 1790; TA-1790;

Chemical formula : C23H26ClN7O3;

Details

Origin ID

C74354;

UMLS CUI

C2698280;

Automatic exact mappings (from CISMeF team)
- Product containing avanafil (medicinal product) [SNOMED CT concept]
CISMeF manual mappings
- Avanafil (substance) [SNOMED CT concept]
Currated CISMeF NLP mapping
- Avanafil [ICD-11 Extension code]
- Avanafil [SMS substance]
- avanafil [International Nonproprietary Name]
- avanafil [MeSH Supplementary Concept]
- avanafil [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Avanafil (substance) [SNOMED CT concept]
- Product containing avanafil (medicinal product) [SNOMED CT concept]
- avanafil [MeSH Supplementary Concept]
- avanafil [MeSH concept]
- avanafil [ATC Code]
- avanafil [International Nonproprietary Name]
Validated automatic mappings to BTNT
- avanafil [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- cGMP-Specific 3',5'-Cyclic Phosphodiesterase [NCIt concept]

Keyword's position in hierarchy(ies) :

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