Sulindac - CISMeF

Preferred Label : Sulindac;

NCIt synonyms : (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid; cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid; Sulindac Sulfoxide;

NCIt definition : A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. (NCI04);

Alternative definition : NCI-GLOSS: A nonsteroidal anti-inflammatory drug (NSAID) that is being studied as a treatment for cancer.;

UNII : 184SNS8VUH;

InChIKey : MLKXDPUZXIRXEP-MFOYZWKCSA-N;

CAS number : 38194-50-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 38194-50-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Aflodac; Novo-Sundac; Reumofil; Arthrocine; Apo-Sulin; Sulreuma; Algocetil; Artribid; Reumyl; Citireuma; Imbaral; Clinoril; Clisundac; Sulinol; Sudac;

Molecule name : MK-231;

Chemical formula : C20H17FO3S;

ChEBI ID : CHEBI:9352;

Codes from synonyms : CDR0000045372; 00516;

Details

Origin ID

C850;

UMLS CUI

C0038792;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing sulindac (medicinal product) [SNOMED CT concept]
- Sulindac [ICD-11 Extension code]
- Sulindac [LOINC component]
- Sulindac (substance) [SNOMED CT concept]
- sulindac [ATC Code]
- sulindac [Substance BNPC]
- sulindac [MeSH concept]
- sulindac [MeSH Descriptor]
- sulindac [SNOMED Notion]
Validated automatic mappings to BTNT
- sulindac [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- cGMP-Specific 3',5'-Cyclic Phosphodiesterase [NCIt concept]
is_component_of_chemotherapy_regimen
- Docetaxel/Sulindac [NCIt concept]
- Eflornithine/Sulindac [NCIt concept]
- Lovastatin/Sulindac [NCIt concept]
- Sulindac/Tamoxifen [NCIt concept]
- Sulindac/Thalidomide [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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