Preferred Label : Sulindac;

NCIt synonyms : (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid; cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid; Sulindac Sulfoxide;

NCIt definition : A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. (NCI04);

Alternative definition : NCI-GLOSS: A nonsteroidal anti-inflammatory drug (NSAID) that is being studied as a treatment for cancer.;

UNII : 184SNS8VUH;

InChIKey : MLKXDPUZXIRXEP-MFOYZWKCSA-N;

CAS number : 38194-50-2;

Drug name : Aflodac; Novo-Sundac; Reumofil; Arthrocine; Apo-Sulin; Sulreuma; Algocetil; Artribid; Reumyl; Citireuma; Imbaral; Clinoril; Clisundac; Sulinol; Sudac;

Molecule name : MK-231;

Chemical formula : C20H17FO3S;

ChEBI ID : CHEBI:9352;

Codes from synonyms : CDR0000045372; 00516;

Details


Keyword's position in hierarchy(ies) : arborescence

Main resources

You can consult :


https://campus.neurochirurgie.fr/article1738.html
2023
France
audiovisual aids
Technique
Average Concentration from T1 to T2 Normalized by Weight
Alprostadil
suggestive of
Intramedullary
Average Concentration Normalized by Weight-Adjusted Dose
Cavernous Hemangioma
Relevance
Average Concentration Normalized by Dose
indication of
hemangioma, cavernous
Average Concentration Normalized by Weight
indicators and reagents
Intramedullary Route of Administration
Sulindac

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08/05/2025


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