sulindac - CISMeF

Preferred Label : sulindac;

MeSH definition : A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.;

CISMeF synonym : merck brand of sulindac; merck sharp & dohme brand of sulindac; cahill may roberts brand of sulindac; alphapharm brand of sulindac; apotex brand of sulindac; kendrick brand of sulindac; novopharm brand of sulindac; Nu-Pharm brand of sulindac; nu pharm brand of sulindac; chemia brand of sulindac;

MeSH hyponym : kenalin; arthrobid; copal; aclin; Novo-Sundac; Apo-Sulin; clinoril; sulindal; Nu-Sulindac; MK-231; Apo Sulin; Arthrocine; Klinoril; Chibret; MK 231; MK231; Novo Sundac; Nu Sulindac;

MeSH CAS label : 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-, (Z)-;

MeSH Related Number : 38194-50-2 (Sulindac);

Registry Number MeSH : 38194-50-2;

Wikipedia link : https://en.wikipedia.org/wiki/Sulindac;

Codes EINECS : 253-819-2;

Is substance : O;

UNII : 184SNS8VUH;

InChIKey : MLKXDPUZXIRXEP-MFOYZWKCSA-N;

Details

Origin ID

D013467;

UMLS CUI

C0038792;

ATC code(s)
- sulindac [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
CISMeF manual mappings
- Sulindac adverse reaction (disorder) [SNOMED CT concept]
- Sulindac measurement (procedure) [SNOMED CT concept]
- Sulindac poisoning (disorder) [SNOMED CT concept]
- sulindac [Substance BNPC]
Pharmacological action(s)
- antineoplastic agents [MeSH Descriptor]
- cyclooxygenase inhibitors [MeSH Descriptor]
Record concept(s)
- Apo-Sulin [MeSH concept]
- MK-231 [MeSH concept]
- Novo-Sundac [MeSH concept]
- Nu-Sulindac [MeSH concept]
- aclin [MeSH concept]
- arthrobid [MeSH concept]
- clinoril [MeSH concept]
- copal [MeSH concept]
- kenalin [MeSH concept]
- sulindac [MeSH concept]
- sulindal [MeSH concept]
Related MeSH Supplementary Concept(s)
- (5-fluoro-2-methyl-1-(3,5-dimethoxy-4-hydroxybenzylidene)-3-(N-benzyl)indene)acetamide [MeSH Supplementary Concept]
- (5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride [MeSH Supplementary Concept]
- 2-(1-benzylidene-5-bromo-2-methyl-1H-inden-3-yl)acetic acid [MeSH Supplementary Concept]
- 5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid 4-(5-thioxo-5H-1,2-dithiol-3-yl)-phenyl ester [MeSH Supplementary Concept]
- K-80003 [MeSH Supplementary Concept]
- OXT-328 [MeSH Supplementary Concept]
- S-sulindac [MeSH Supplementary Concept]
- nitrosulindac [MeSH Supplementary Concept]
- sulindac derivative IND 12 [MeSH Supplementary Concept]
- sulindac sulfide [MeSH Supplementary Concept]
- sulindac sulfide amide [MeSH Supplementary Concept]
- sulindac sulfone [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing sulindac (medicinal product) [SNOMED CT concept]
- Sulindac [ICD-11 Extension code]
- Sulindac [NCIt concept]
- Sulindac [LOINC component]
- Sulindac (substance) [SNOMED CT concept]
- sulindac [ATC Code]
- sulindac [Substance BNPC]
- sulindac [SNOMED Notion]
Validated automatic mappings to BTNT
- sulindac [ATC Code]

Keyword's position in hierarchy(ies) :

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