Alprostadil - CISMeF

Preferred Label : Alprostadil;

NCIt synonyms : Prostaglandin E1; (11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic Acid;

NCIt related terms : Muse (intraurethral alprostadil suppository); PGE1;

NCIt definition : The naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Alprostadil is a potent vasodilator agent that increases peripheral blood flow, inhibits platelet aggregation, and induces bronchodilation. Used in the treatment of erectile dysfunction, this agent produces corporal smooth muscle relaxation by binding to PGE receptors, resulting in the activation of adenylate cyclase and the subsequent accumulation of 3'5'-cAMP.;

Alternative definition : NCI-GLOSS: A drug that is used to treat impotence (inability to have an erection) and is being studied in the treatment of sexual problems in men who have had surgery for prostate cancer. It is a type of vasodilator.;

UNII : F5TD010360;

InChIKey : GMVPRGQOIOIIMI-DWKJAMRDSA-N;

CAS number : 745-65-3;

Drug name : MUSE; Caverject;

Chemical formula : C20H34O5;

NSC code : 165559;

ChEBI ID : CHEBI:15544;

Codes from synonyms : 05594; CDR0000613197; CDR0000613199; CDR0000613198;

Details

Origin ID

C28816;

UMLS CUI

C0002335;

Automatic exact mappings (from CISMeF team)
- Prostaglandin E1 [ICHI extension code]
- hemangioma, cavernous [MeSH Descriptor]
- museums [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Alprostadil [ICD-11 Extension code]
- Alprostadil (substance) [SNOMED CT concept]
- Product containing alprostadil (medicinal product) [SNOMED CT concept]
- Prostaglandin E1 [ICD-11 Extension code]
- Prostaglandin E1 [LOINC component]
- Prostaglandin E>1< preparation (product) [Inactive SNOMED CT concept]
- alprostadil [ATC Code]
- alprostadil [ATC Code]
- alprostadil [Substance BNPC]
- alprostadil [MeSH concept]
- alprostadil [MeSH Descriptor]
- prostaglandin pge1 [SNOMED Notion]
Validated automatic mappings to BTNT
- alprostadil [ATC Code]
- alprostadil [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Expanded Prostate Cancer Index Composite, Sexual Medications/Devices Supplement [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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