Prostatic Acid Phosphatase

Preferred Label : Prostatic Acid Phosphatase;

NCIt synonyms : ACPP; PAP; TMPase; 5'-Nucleotidase; 5'-NT; Thiamine Monophosphatase; Ecto-5'-Nucleotidase; Protein Tyrosine Phosphatase ACP3; ACP3; Acid Phosphatase 3; EC 3.1.3.5; EC 3.1.3.2; EC 3.1.3.48;

NCIt definition : Prostatic acid phosphatase (386 aa, 45 kDa) is encoded by the human ACP3 gene. This protein is involved in the dephosphorylation of both lipids and tyrosine and has ecto-5'-nucleotidase activity.;

Alternative definition : NCI-GLOSS: An enzyme produced by the prostate. It may be found in increased amounts in men who have prostate cancer.;

NCIt note : Prostatic acid phosphatase precursor catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. ACPP is synthesized under androgen regulation and secreted by the epithelial cells of the prostrate gland. (EntrezGene); Prostatic acid phosphatase is proteolytically cleaved in seminal fluid, which produces several peptides. One peptide, PAPf39 a 39 amino acid peptide comprised of residues 248-286, forms fibrils resembling amyloid beta-sheets. This peptide is also known as SEVI (semen-derived enhancer of viral infection) because the fibrils bind to HIV (and possibly other) virions and promote viral attachment to and infection of target cells. (UniProt);

Codes from synonyms : CDR0000044451; CDR0000046541;

Details

Origin ID

C18015;

UMLS CUI

C1740167;

Automatic exact mappings (from CISMeF team)
- 5'-Nucleotidase [LOINC component]
- 5'-Nucleotidase [MeSH Descriptor]
- 5'-Nucleotidase [MeSH concept]
- 5'-nucleotidase [SNOMED Notion]
- 5'-nucleotidase [Artificial nutrition thesaurus concept]
- 5'-nucleotidase [EMDN type]
- 5'-nucleotidase [medical devices type]
- 5'-nucleotidase (substance) [SNOMED CT concept]
- 5'nucleotidase [MedDRA Preferred Term]
- Development- and differentiation-enhancing factor 2 [OMIM gene]
- GLI family zinc finger 3 [ORDO Gene]
- Lymphocyte antigen CD73 (substance) [SNOMED CT concept]
- Pdgfa-associated protein 1 [OMIM gene]
- Phosphatase, prostate-specific acid [OMIM gene]
- Pituitary adenoma 1, multiple types [OMIM Phenotype]
- Poly(a) polymerase, alpha [OMIM gene]
- Prostatic acid phosphatase increased [MedDRA Preferred Term]
- Pyrimidine-5'-Nucleotidase [LOINC component]
- Regenerating islet-derived 3-alpha [OMIM gene]
- acid phosphatase 3 [HGNC gene]
- polyphosphate:AMP phosphotransferase activity [GO term]
- pulmonary alveolar proteinosis [MeSH Descriptor]
- pulmonary wedge pressure [MeSH Descriptor]
- thiamine monophosphatase [MeSH concept]
- thiamine monophosphatase [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- Acid phosphatase.prostatic [LOINC component]
- Prostatic acid phosphatase [MedDRA Preferred Term]
- prostatic acid phosphatase [MeSH concept]
- prostatic acid phosphatase [MeSH Supplementary Concept]
OMIM relation
- Phosphatase, prostate-specific acid [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- ACPP protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ACP3 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Phosphatase Family Gene [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
gene_product_has_chemical_classification
- 5' Nucleotidase Family [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Tumor Marker [NCIt concept]
gene_product_is_element_in_pathway
- Riboflavin Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Dephosphorylation [NCIt concept]
- Hydrolysis [NCIt concept]
- Nucleotide Metabolic Process [NCIt concept]
- Protein Metabolism Process [NCIt concept]
is_target
- APC8015F [NCIt concept]
- ChAdOx1-PSA/PAP/STEAP1/5T4 Prostate Cancer Vaccine ChAdOx1-PCAQ [NCIt concept]
- MVA-PSA/PAP/STEAP1/5T4 Prostate Cancer Vaccine MVA-PCAQ [NCIt concept]
- PAP/PSA-expressing Arenaviral Vectors HB-302/HB-301 [NCIt concept]
- Prostatic Acid Phosphatase-Sargramostim Fusion Protein PA2024 [NCIt concept]
- Sipuleucel-T [NCIt concept]
- pTVG-HP Plasmid DNA Vaccine [NCIt concept]

Keyword's position in hierarchy(ies) :

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