Preferred Label : APC8015F;
NCIt definition : A cell-based vaccine composed of previously frozen autologous antigen-presenting peripheral
blood mononuclear cells (enriched for a dendritic cell fraction) that have been exposed
to a recombinant protein consisting of granulocyte-macrophage colony-stimulating factor
(GM-CSF) fused to prostatic-acid phosphatase (PAP), a protein expressed by prostate
cancer cells. Upon administration, the vaccine may stimulate an antitumor T-cell response
against tumor cells expressing PAP.;
Alternative definition : NCI-GLOSS: A vaccine made from immune system cells taken from a patient with prostate
cancer and frozen for future use. The cells are treated in the laboratory with a growth
factor attached to a protein called prostatic-acid phosphatase (PAP), which is found
on prostate cancer cells. When APC8015F is injected into the patient, it may cause
T cells (a type of white blood cell) to kill tumor cells that have PAP on them.;
Molecule name : APC8015F; APC 8015F;
Codes from synonyms : CDR0000561410;
Origin ID : C48640;
UMLS CUI : C1541593;
Semantic type(s)
- concept_is_in_subset
- has_target
