PAP/PSA-expressing Arenaviral Vectors HB-302/HB-301

Preferred Label : PAP/PSA-expressing Arenaviral Vectors HB-302/HB-301;

NCIt synonyms : HB-302/HB-301; HB-301/HB-302; PAP/PSA-expressing Arenaviral Vectors HB-300;

NCIt definition : An alternating, 2-vector replicating arenaviral combination agent composed of two genetically engineered replicating vectors: HB-301, which is based on the arenavirus lymphocytic choriomeningitis virus (LCMV), and HB-302, which is based on the arenavirus Pichinde virus (PICV), and both expressing the same transgenes encoding for the two prostate cancer-associated antigens prostatic acid phosphatase (PAP) and prostate specific antigen (PSA), with potential immunomodulating and antineoplastic activities. Upon intravenous administration, the PAP/PSA-expressing arenaviral vectors HB-302/HB-301 express PSA and PAP peptides and cause antibody-mediated and cytotoxic T-lymphocyte (CTL)-mediated immune responses against prostate cancer cells expressing PSA and PAP.;

Molecule name : HB-300; HB 300;

NCI Metathesaurus CUI : CL1905238;

Details

Origin ID

C191720;

UMLS CUI

C5784681;

Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Prostate-Specific Antigen [NCIt concept]
- Prostatic Acid Phosphatase [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients