Exosome Component 10

Preferred Label : Exosome Component 10;

NCIt synonyms : Autoantigen PM-SCL; Polymyositis/Scleroderma Autoantigen 2; Polymyositis/Scleroderma Autoantigen 100 kDa; EC 3.1.13.-; P100 Polymyositis-Scleroderma Overlap Syndrome-Associated Autoantigen; Autoantigen PM/Scl; EXOSC10;

NCIt related terms : P100 POLYMYOSITIS-SCLERODERMA AUTOANTIGEN; PM/Scl-100; PM/Scl 2;

NCIt definition : Exosome component 10 (885 aa, 101 kDa) is encoded by the human EXOSC10 gene. This protein plays a role in the maturation and degradation of RNA.;

Alternative definition : CDISC: An antigen encoded by the EXOSC10 gene and is involved in the maturation and degradation of RNA. It can be considered as an autoantigen and is commonly associated with the autoimmune disease polymyositis-scleroderma overlap syndrome.;

NCIt note : Antinucleolar antibodies targeting exosome component 10 are found in patients with scleroderma or polymyositis, or in patients suffering from overlap of these 2 syndromes. (OMIM);

Détails

Origin ID

C181689;

UMLS CUI

C0379610;

OMIM relation
- Exosome component 10 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- EXOSC10 protein, human [MeSH Supplementary Concept]
- EXOSC10 protein, human [MeSH concept]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- EXOSC10 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Ribonuclease Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleolus [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- 3'-5' Exonuclease [NCIt concept]
- Hydrolase [NCIt concept]
- Protein Complex Subunit [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- RNA Degradation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- RNA Degradation [NCIt concept]
- RNA Processing [NCIt concept]

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