NCIt related terms : P100 POLYMYOSITIS-SCLERODERMA AUTOANTIGEN; PM/Scl-100; PM/Scl 2;
NCIt definition : Exosome component 10 (885 aa, 101 kDa) is encoded by the human EXOSC10 gene. This
protein plays a role in the maturation and degradation of RNA.;
Alternative definition : CDISC: An antigen encoded by the EXOSC10 gene and is involved in the maturation and
degradation of RNA. It can be considered as an autoantigen and is commonly associated
with the autoimmune disease polymyositis-scleroderma overlap syndrome.;
NCIt note : Antinucleolar antibodies targeting exosome component 10 are found in patients with
scleroderma or polymyositis, or in patients suffering from overlap of these 2 syndromes.
(OMIM);