RNA Degradation Pathway

Preferred Label : RNA Degradation Pathway;

NCIt related terms : RNA degradation;

Alternative definition : KEGG: The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex.;

KEGG ID : hsa03018;

Details

Origin ID

C91512;

UMLS CUI

C2984321;

Automatic exact mappings (from CISMeF team)
- RNA catabolic process [GO term]
- RNA degradation [MeSH concept]
- rna stability [MeSH Descriptor]
Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- 5'-3' Exoribonuclease 1 [NCIt concept]
- 5'-3' Exoribonuclease 2 [NCIt concept]
- 60 kDa Heat Shock Protein, Mitochondrial [NCIt concept]
- CCR4-NOT Transcription Complex Subunit 3 [NCIt concept]
- Exosome Complex Component RRP40 [NCIt concept]
- Exosome Complex Component RRP45 [NCIt concept]
- Exosome Complex Component RRP46 [NCIt concept]
- Exosome Complex Exonuclease RRP44 [NCIt concept]
- Exosome Component 10 [NCIt concept]
- Gamma-Enolase [NCIt concept]
- Poly(A)-Specific Ribonuclease PARN [NCIt concept]
- Polyadenylate-Binding Protein 1 [NCIt concept]
- Probable ATP-Dependent RNA Helicase DDX6 [NCIt concept]
- Protein Tob2 [NCIt concept]
- Superkiller Complex Protein 2 [NCIt concept]
- Terminal Nucleotidyltransferase 4B [NCIt concept]
pathway_has_gene_element
- CNOT3 wt Allele [NCIt concept]
- DDX6 wt Allele [NCIt concept]
- DIS3 wt Allele [NCIt concept]
- ENO2 wt Allele [NCIt concept]
- EXOSC10 wt Allele [NCIt concept]
- EXOSC3 wt Allele [NCIt concept]
- EXOSC5 wt Allele [NCIt concept]
- EXOSC9 wt Allele [NCIt concept]
- HSPD1 wt Allele [NCIt concept]
- PABPC1 wt Allele [NCIt concept]
- PARN wt Allele [NCIt concept]
- SKIC2 wt Allele [NCIt concept]
- TENT4B wt Allele [NCIt concept]
- TOB2 wt Allele [NCIt concept]
- XRN1 wt Allele [NCIt concept]
- XRN2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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