Polyadenylate-Binding Protein 1

Preferred Label : Polyadenylate-Binding Protein 1;

NCIt synonyms : PABPC1; Poly(A)-Binding Protein 1; PABP-1;

NCIt definition : Polyadenylate-binding protein 1 (636 aa, 71 kDa) is encoded by the human PABPC1 gene. This protein is involved in binding to the poly(A) tail of mRNA.;

NCIt note : A number of viruses downregulate the host mRNA translational machinery by inhibiting cellular polyadenylate-binding protein 1 activity through a variety of mechanisms. (UniProt);

NCI Metathesaurus CUI : CL541562;

Details

Origin ID

C143074;

UMLS CUI

C4552666;

Automatic exact mappings (from CISMeF team)
- Poly(A)-Binding protein I [MeSH Descriptor]
- Polyadenylate-binding protein, cytoplasmic, 1 [OMIM gene]
OMIM relation
- Polyadenylate-binding protein, cytoplasmic, 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- PABPC1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- RNA Recognition Motif [NCIt concept]
gene_product_is_element_in_pathway
- RNA Degradation Pathway [NCIt concept]
- eIF4 Regulation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Ligand Binding [NCIt concept]
- Nonsense-Mediated Decay [NCIt concept]
- RNA Binding [NCIt concept]
- RNA Polyadenylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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