Nonsense-Mediated Decay

Preferred Label : Nonsense-Mediated Decay;

NCIt synonyms : NMD; Nonsense-Mediated mRNA Decay;

NCIt definition : Nonsense-Mediated Decay is the widely conserved process in eukaryotes whereby certain alternatively spliced RNAs, some selenoprotein mRNAs, and nonsense or frame-shift mutations that result in premature translation termination signal rapid mRNA degradation; the mechanism that eliminates mRNAs with premature termination codons, reducing the accumulation of deleterious proteins and their effects. NMD is initiated during translation when hUpf proteins phosphorylated by SMG proteins cooperate with an exon-junction complex to identify mRNAs with premature stop codons and mark the transcript for rapid decay. Degrading mRNAs from both ends, NMD involves decapping, deadenylating, and exonucleolytic activities.;

Details

Origin ID

C29648;

UMLS CUI

C1158013;

Automatic exact mappings (from CISMeF team)
- macular degeneration [MeSH Descriptor]
- nonsense mediated mRNA decay [MeSH Descriptor]
- nonsense mediated mRNA decay [MeSH concept]
- nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [GO term]
- nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay [GO term]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO term]
Semantic type(s)
- Genetic Function [UMLS semantic type]
UMLS correspondences (same concept)
- nonsense mediated mRNA decay [MeSH concept]
- nonsense mediated mRNA decay [MeSH Descriptor]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO term]
biological_process_involves_gene_product
- 40S Ribosomal Protein S20 [NCIt concept]
- Eukaryotic Peptide Chain Release Factor GTP-Binding Subunit ERF3A [NCIt concept]
- Eukaryotic Translation Initiation Factor 3 Subunit E [NCIt concept]
- Polyadenylate-Binding Protein 1 [NCIt concept]
- RNA-Binding Protein 8A [NCIt concept]
- Superkiller Complex Protein 2 [NCIt concept]
process_involves_gene
- GSPT1 Gene [NCIt concept]
- GSPT1 wt Allele [NCIt concept]
- PABPC1 Gene [NCIt concept]
- PABPC1 wt Allele [NCIt concept]
- RBM8A Gene [NCIt concept]
- RBM8A wt Allele [NCIt concept]
- RPS20 Gene [NCIt concept]
- RPS20 wt Allele [NCIt concept]
- SKIC2 Gene [NCIt concept]
- SKIC2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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