Eukaryotic Peptide Chain Release Factor GTP-Binding Subunit ERF3A

Preferred Label : Eukaryotic Peptide Chain Release Factor GTP-Binding Subunit ERF3A;

NCIt synonyms : Eukaryotic Release Factor 3a; Peptide Chain Release Factor 3A; Eukaryotic Peptide Chain Release Factor Subunit 3a; GSPT1; G1 to S Phase Transition Protein 1 Homolog; eRF3a;

NCIt definition : Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (499 aa, 56 kDa) is encoded by the human GSPT1 gene. This protein plays a role in the termination of protein translation and the nonsense-mediated decay of mRNA.;

Details

Origin ID

C190800;

UMLS CUI

C1312767;

OMIM relation
- G1- to s-phase transition 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- GSPT1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- GSPT1 Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Translation Process Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_biochemical_function
- GTPase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- GTP Binding [NCIt concept]
- Hydrolysis [NCIt concept]
- Nonsense-Mediated Decay [NCIt concept]
- Translation Process [NCIt concept]
- Translational Regulation [NCIt concept]
is_target
- Anti-HER2 GSPT1 Degrader ORM-5029 [NCIt concept]

Keyword's position in hierarchy(ies) :

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