5'-3' Exonuclease

Preferred Label : 5'-3' Exonuclease;

NCIt synonyms : Five Prime-Three Prime Exonuclease;

NCIt definition : Five Prime-Three Prime Exonucleases specifically catalyze the hydrolysis of terminal phosphodiester bonds of nucleic acids. Human XRN1 and XRN2 are similar to mouse Dhm1 and yeast dhp1, involved in homologous recombination, meiosis, telomere maintenance, RNA synthesis and RNA trafficking. XRN1 localizes to cytoplasmic complexes of mRNA-degrading enzymes and prefers RNA over DNA substrates. XRN2 promotes transcription termination by 5-prime to 3-prime exonuclease activity and autocatalytic cotranscriptional cleavage that may induce dissociation of RNA polymerase II from the DNA template, but function has not yet been fully determined.;

Details

Origin ID

C16243;

UMLS CUI

C0094209;

Automatic exact mappings (from CISMeF team)
- Phosphodiesterase I (substance) [SNOMED CT concept]
- Spleen exonuclease (substance) [SNOMED CT concept]
- exodeoxyribonuclease v [MeSH Descriptor]
- exonucleases [MeSH Descriptor]
- phosphodiesterase i [MeSH Descriptor]
- spleen exonuclease [MeSH Supplementary Concept]
Biochemical function of gene products
- 5' Exonuclease Apollo [NCIt concept]
- 5'-3' Exoribonuclease 1 [NCIt concept]
- 5'-3' Exoribonuclease 2 [NCIt concept]
- DNA-(Apurinic or Apyrimidinic Site) Lyase [NCIt concept]
- Exonuclease 1 [NCIt concept]
- Flap Endonuclease 1 [NCIt concept]
- Protein Artemis [NCIt concept]
Currated CISMeF NLP mapping
- 3'-5'-Exonucleases [MeSH concept]
- 5'-3'-Exonucleases [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- 5'-3'-Exonucleases [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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