Iduronate 2-Sulfatase

Preferred Label : Iduronate 2-Sulfatase;

NCIt synonyms : Alpha-L-Iduronate Sulfate Sulfatase; Idursulfase; IDS;

NCIt definition : Iduronate 2-sulfatase (550 aa, 62 kDa) is encoded by the human IDS gene. This protein is involved in the degradation of glycosaminoglycans.;

NCIt note : The full length protein is an inactive precursor that can be cleaved to form the enzymatically active iduronate 2-sulfatase, which is comprised of both a 42 kDa and a 14 kDa chain. (UniProt);

Details

Origin ID

C75606;

UMLS CUI

C1429223;

OMIM relation
- Mucopolysaccharidosis, type II [OMIM Phenotype]
See also inter- (CISMeF)
- Idursulfase [SMS substance]
- Product containing idursulfase (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- IDS protein, human [MeSH concept]
- IDS protein, human [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- idursulfase [ATC Code]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- IDS Gene [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Glycosaminoglycan Degradation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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