Protein Tyrosine Phosphatase

Preferred Label : Protein Tyrosine Phosphatase;

NCIt synonyms : Tyrosine O-Phosphate Phosphatase; Phosphotyrosylprotein Phosphatase; Phosphoprotein Phosphatase (Phosphotyrosine); [Phosphotyrosine]Protein Phosphatase; PTPase; Phosphotyrosine Phosphatase; Tyrosylprotein Phosphatase; Protein Phosphotyrosine Phosphatase; Protein-Tyrosine-Phosphatase; Phosphotyrosine Protein Phosphatase; PTP-Phosphatase; PPT-Phosphatase; Tyrosine-Specific Protein Phosphatase; PTPs;

NCIt definition : Encoded by Protein Tyrosine Phosphatase Genes, Protein Tyrosine Phosphatases are a group of enzymes that specifically remove tyrosine-bound phosphate groups from many phosphoproteins, including many enzymes phosphorylated by a tyrosine kinase. Together with protein tyrosine kinases, Tyrosine Phosphatases regulate tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis. (NCI);

Details

Origin ID

C17444;

UMLS CUI

C0085536;

Automatic exact mappings (from CISMeF team)
- 6-pyruvoyl-tetrahydropterin synthase [OMIM gene]
- 6-pyruvoyltetrahydropterin synthase [ORDO Gene]
- 6-pyruvoyltetrahydropterin synthase [MeSH Supplementary Concept]
- 6-pyruvoyltetrahydropterin synthase (substance) [SNOMED CT concept]
- PTPRF interacting protein alpha 3 [HGNC gene]
- Thrombotic thrombocytopenic purpura [ORDO Disease]
- partial thromboplastin time [MeSH Descriptor]
- protein tyrosine phosphatase, Non-Receptor type 13 [MeSH Descriptor]
- protein tyrosine phosphatases [MeSH Descriptor]
- protein tyrosine phosphatases [MeSH concept]
- purpura, thrombotic thrombocytopenic [MeSH Descriptor]
- tyrosine phosphate hydrolase [MeSH Supplementary Concept]
- tyrosine-o-phosphate phosphatase [MeSH concept]
Biochemical function of gene products
- Protein Tyrosine Phosphatase Type IVA [NCIt concept]
Currated CISMeF NLP mapping
- protein-tyrosine-phosphatase [SNOMED Notion]
False automatic mappings
- Protein-tyrosine-phosphatase (substance) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Protein-tyrosine-phosphatase (substance) [SNOMED CT concept]
- protein tyrosine phosphatases [MeSH concept]
- protein tyrosine phosphatases [MeSH Descriptor]
- protein-tyrosine-phosphatase [SNOMED Notion]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Phosphatase Family Gene [NCIt concept]
- Protein Phosphatase Gene [NCIt concept]
- Protein Tyrosine Phosphatase Gene [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Dephosphorylation [NCIt concept]
- Hydrolysis [NCIt concept]
- Protein Dephosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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