DNA Replication ATP-Dependent Helicase/Nuclease DNA2

Preferred Label : DNA Replication ATP-Dependent Helicase/Nuclease DNA2;

NCIt synonyms : DNA Replication Helicase 2 Homolog; DNA Replication Nuclease DNA2; DNA2-Like Helicase; DNA Replication ATP-Dependent Helicase DNA2; hDNA2; DNA Replication ATP-Dependent Helicase-Like Homolog; DNA2;

NCIt definition : DNA replication ATP-dependent helicase/nuclease DNA2 (1060 aa, 120 kDa) is encoded by the human DNA2 gene. This protein is involved in Okazaki fragment processing and DNA double-strand break repair.;

NCIt note : DNA replication ATP-dependent helicase/nuclease DNA2 is involved in repair of both nuclear and mitochondrial DNA.; DNA replication ATP-dependent helicase/nuclease DNA2 has both DNA 5'-3' helicase (EC 3.6.4.12) and 5'-3' endonuclease (EC 3.1.-.-) activities. (UniProt);

Details

Origin ID

C117093;

UMLS CUI

C1701412;

OMIM relation
- Dna replication helicase/nuclease 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- DNA2 protein, human [MeSH Supplementary Concept]
- DNA2 protein, human [MeSH concept]
gene_encodes_gene_product
- DNA2 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Helicase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleoplasm [NCIt concept]
gene_product_has_biochemical_function
- ATPase [NCIt concept]
- DNA Repair Endonuclease [NCIt concept]
- Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- DNA Replication Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- ATP Hydrolysis [NCIt concept]
- DNA Binding [NCIt concept]
- DNA Maintenance Process [NCIt concept]
- DNA Repair [NCIt concept]
- DNA Replication [NCIt concept]
- Hydrolysis [NCIt concept]
- Nucleic Acid Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

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